Spectroscopic identification of brominated, non-brominated alkaloids and evaluation of antimicrobial activity of Eudistomin-I, Eudistomin H, from green ascidian Eudistoma viride

ABSTRACT

Several eudistomin groups of compounds were identified from the organic extract of green ascidian Eudistoma virideusing MALDI-TOF mass spectrometry. Apart from this, a series of unexplored mass traces belonging to differentnovel molecules were discovered with and without bromine moiety. The crude extract and its purified fractions wereevaluated for the presence of antimicrobial activity against several human pathogenic bacteria. The results suggest thatEudistomin-H and its non-brominated form Eudistomin-I was potentially active against a panel of pathogenic bacteria.