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Safety evaluation of polysaccharides isolated from the water extract of Argemone mexicana L. (Papaveraceae) in Drosophila melanogaster
Article | IMSEAR | ID: sea-210685
ABSTRACT
Recently, the plant polysaccharides have attracted attention due to their important bioactivities. The literature hasshown several pharmacological activities of Argemone mexicana extracts and its components but very few dataon its polysaccharides. The current study aimed to evaluate the safety of polysaccharides from A. mexicana. Fivepolysaccharides [High molecular weight (polysaccharide fraction) of the water extract from Argemone mexicana 1( HMAm1), HMAm2, HMAm3, HMAmA1, and HMAmA2] were fractionated from A. mexicana aerial parts by usingaccelerated solvent extractor procedure followed by ion exchange chromatography of the water decoction extract.The safety assay was carried out using Drosophila melanogaster exposed to the polysaccharides at 12.5 and 25 µg/ml for 72 hours against a negative control (1% DMSO). After the exposure period, the survival rate and the locomotorcapacity of flies were determined. At the end of 72 hours of treatment, all polysaccharide fractions at both dosespresented a survival percent of more than 94%. In addition, these polysaccharide fractions affected very little thelocomotor performance of the flies. At both doses, HMAm2 presented the highest safety for the flies, while HMAm3was the least. These findings revealed that polysaccharides from A. mexicana are nontoxic.

Full text: Available Index: IMSEAR (South-East Asia) Country/Region as subject: Mexico Year: 2020 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Country/Region as subject: Mexico Year: 2020 Type: Article