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The research progress on the mechanism of adenosine A1 receptor-mediated calcitonin gene-related peptide to relieve migraine
Article | IMSEAR | ID: sea-211931
ABSTRACT
Currently, the pathogenesis of migraine is unclear. The trigeminal vascular reflex theory is the dominant pathogenesis theory, and its core parts are neurogenic inflammation and pain sensitisation. Calcitonin gene related peptide (CGRP) is the most powerful vasodilating peptide in brain circulation. It is also a marker of trigeminal nerve microvascular activation that plays a synergistic role in the pathogenesis of migraine. Adenosine A1 receptor (A1R) can inhibit the release of CGRP in the trigeminal nerve vascular system to alleviate migraine by mediating adenosine. This review summarises the progress of research on the alleviation of migraine by using A1R-mediated CGRP.

Full text: Available Index: IMSEAR (South-East Asia) Year: 2019 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Year: 2019 Type: Article