Evaluation of serum sex hormones and CD4+ count among HIV patients on HAART, HAART naive patients and apparently healthy subjects in Sokoto, Nigeria
Article
| IMSEAR
| ID: sea-212155
ABSTRACT
Background:
Acquired Immunodeficiency Syndrome (AIDS) is a chronic disease associated with Human Immunodeficiency Virus (HIV) which progressively induces depletion of CD4+ T cells, and increased vulnerability to opportunistic infections. Previous reported studies associated HIV-infected men with sexual dysfunction; hypogonadism is the most common endocrinological disorders. Its prevalence remains poorly defined and widely ranging from different studies.Methods:
This study evaluated a total of 135 serum sex hormones (testosterone, estrogen, follicle stimulating hormone and luteinizing hormone) and its correlation with CD4+ counts among HIV patients on HAART, HAART naïve patients and negative control subjects (n=45). CD4+ cell counts were estimated using standard flow cytometry method and serum sex hormones by competitive enzyme immunoassay technique.Results:
There were significantly lower testosterone and CD4+ levels (p<0.05) among HIV positive HAART naïve men compared to negative control. LH and FSH indicated significant increased (p<0.05) among HIV positive men on HAART.Conclusions:
Antiretroviral therapy improves sexual functions in males infected with human immunodeficiency virus. Hence, further study to evaluate its effects on other sexual behaviors.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Year:
2020
Type:
Article
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