Naturally occurring anti-native DNA antibodies in SLE binding Z-DNA.
Article
in English
| IMSEAR
| ID: sea-21380
ABSTRACT
A high degree of specificity of circulating anti-DNA antibody for double stranded DNA in the sera of SLE patients was found, as compared to single stranded polymer. The antibody recognized brominated DNA, a polymer that appears to attain Z-conformation as indicated on the basis of UV absorption characteristics. The existence in native DNA of regions undergoing B----Z transition has been detected.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Autoantibodies
/
Humans
/
DNA
/
Lupus Erythematosus, Systemic
/
Antibody Specificity
/
Nucleic Acid Conformation
Language:
English
Year:
1990
Type:
Article
Similar
MEDLINE
...
LILACS
LIS