Facial paralysis probably related to systemic isotretinoin

ABSTRACT

We report a patient with severe acne who developed facial paralysis after two months of treatment with oral isotretinoin. Drug withdrawal resulted in a complete clinical recovery. Our case and a review of the literature indicate that oral isotretinoin might be capable of causing a dysfunction of predominantly sensory nerve fibers in some individuals. Clinicians should be aware of possible neurological sensorial symptoms during isotretinoin therapy