Overview of genomics and post-genomics research on type 2 diabetes mellitus: Future perspectives and a framework for further studies

ABSTRACT

In this review, we briefly outlined salient features of pathophysiology and results of the genetic association studies hithertoconducted on type 2 diabetes. Primarily focusing on the current status of genomic research, we briefly discussed the limitedprogress made during the post-genomic era and tried to identify the limitations of the post-genomic research strategies. Wesuggested reanalysis of the existing genomic data through advanced statistical and computational methods and recommended integrated genomics-metabolomics approaches for future studies to facilitate understanding of the gene-environment interactions in the manifestation of the disease. We also propose a framework for research that may be apt fordetermining the effects of urbanization and changing lifestyles in the manifestation of complex genetic disorders like type 2diabetes in the Indian populations and offset the confounding effects of both genetic and environmental factors in thenatural way