α-Helical protein absorption at post-traumatic epileptic foci monitored by Fourier transform infrared mapping
J Biosci
;
2020 Apr; : 1-8
Article
| IMSEAR
| ID: sea-214308
ABSTRACT
Tissue analysis by Fourier transform infrared (FTIR) imaging can determine the biodistribution of molecules,without pre-analytical modification. We aimed to study the infrared spectroscopic changes of a-helical proteinsat post-traumatic epileptic (PTE) foci by FTIR. FITR mapping was applied to detect a-helical proteins in ratbrain tissue samples with post-traumatic epilepsy. Histological examination of brain sections showed that therat model of PTE was successfully established. At the PTE foci, high a-helical absorption regions wereevident, where the color difference and absorption were significantly different from those in the low-absorptionregions. This provided a distinctive and characteristic pattern at the site of lesions. The use of FTIR imagingmeans that it is possible to measure the molecular structural changes resulting from PTE pathologies in tissues,providing a novel adjunct to conventional pathological diagnostic techniques.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Prognostic study
Journal:
J Biosci
Year:
2020
Type:
Article
Similar
MEDLINE
...
LILACS
LIS