14-3-3 proteins mediate the localization of Centrin2 to centrosome
J Biosci
;
2019 Jun; 44(2): 1-10
Article
| IMSEAR
| ID: sea-214382
ABSTRACT
14-3-3e and 14-3-3c localize to the centrosome and regulate centrosome duplication, by inhibiting cdc25C function. As14-3-3c and 14-3-3e form a complex with centrosomal proteins, we asked if this ability was required to regulate centrosomeduplication. The results in this report demonstrate that 14-3-3e and 14-3-3c form a complex with Centrin2 and that thebinding site is located in the N-terminal EF hand in Centrin2, EF1. A Centrin2 mutant that does not form a complex with14-3-3 proteins displays a punctate cytoplasmic localization and does not localize to the centrosome. These results suggestthat in addition to negatively regulating centrosome duplication as previously reported, 14-3-3 proteins might also berequired for centriole biogenesis by regulating the localization of Centrin2 at the centrosome.
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Index:
IMSEAR (South-East Asia)
Journal:
J Biosci
Year:
2019
Type:
Article
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