Study of Myocardial Performance Index in Prediabetes and Its Correlation with Other Cardiovascular Risk Factors.

ABSTRACT

Myocardial performance index (MPI)/Tei index measures the LV systolic and LV diastolic function. Several studies have proved its reliability in evaluating the LV systolic and diastolic performance, with clear benefit over other old indices. It is also helpful in determining the prognosis of heart diseases, especially coronary artery disease. Diabetes affects the heart in several ways. The prevalence of coronary artery disease in a patient with diabetes is well known. The cardiac status in prediabetes is not studied extensively. Hence this study was undertaken to assess the myocardial function in prediabetes using MPI. We wanted to assess myocardial performance index (MPI) in prediabetes and correlate myocardial performance index with cardiovascular risk factors like waist hip ratio (WHR), fasting lipid profile (FLP) and body mass index (BMI).METHODSIn this cross sectional study 200 prediabetics were enrolled as cases and 100 age and sex matched subjects were enrolled as controls. Thorough history, physical examination, biochemical investigations like FBS, PMBS, FLP and Echocardiography for myocardial performance index were done.RESULTSBody mass index (BMI), waist to hip ratio (WHR), total cholesterol, triglycerides, low density lipoprotein (LDL) and very low-density lipoprotein (VLDL) were significantly higher in prediabetes and high-density lipoprotein (HDL) were significantly lower in prediabetes in comparison to controls (p=0.0001). Out of 200 prediabetic subjects, 23 (11.5%) had abnormal MPI which was statistically significant in comparison with controls (p=0.037) There was no correlation of abnormal myocardial performance index with cardiovascular risk factors like BMI, WHR and fasting lipid profile (FLP).CONCLUSIONSPrediabetes had abnormal MPI in comparison to controls. However, no correlation was found between cardiovascular risk factors and MPI.