The Effect of Non-Steroidal Anti-inflammatory Drugs (NSAIDs) on Bone Healing around Osseointegrated Dental Implants - A Systematic Review

ABSTRACT

NSAIDs are considered effective pain-relieving agents after dental implant placement. However, they may have related side effects. We wanted to determine as to whether these agents have a positive or negative impact on the supporting alveolar bone after dental implant placement. METHODSPRISMA flowchart was followed and the clinical question in PICO format was ‘‘Do systemic NSAIDs help or impede the healing of osssointergrated implants?’’. The databases of Ovid, PubMed, Scopus, and Web of Science were used in this systematic literature search for clinical trials. Publications between January 1, 1990 and January 31, 2020 were searched. RESULTSThe initial search resulted in 385 articles. Only four studies were selected for qualitative synthesis after fulfilling the eligibility criteria (three double blind randomized controlled trials (RCTs) and one retrospective cohort study) with 222 patients and 686 implants placed. CONCLUSIONSThe results showed that the administration of NSAIDs post implant placement may not have a significant effect on the supporting bone.