Recommendations of Test of Prostate-specific Antigen along with Histopathological Examination for the Prostate Lesions

ABSTRACT

Introduction: Prostate disease is an important growing health problem, presenting a challenge to urologists, radiologists, and pathologists. Objectives: The aim of the study is to correlate prostatic-specific antigen test with histopathological examination in prostatic lesions and to recommend combine approach for management of the patients of prostatic lesions. Materials and Methods:This was a prospective study conducted at the department of pathology in a tertiary care center over 6 months. Data were collected from histopathology record department. The 2002 WHO classification was used to diagnose and classify prostate tumors. Gleason’s grading system was used for the cases of adenocarcinoma. Results: In our study, a total of 119 cases of prostatic lesions were noticed. The lesions diagnosed were benign prostatic hyperplasia (79% of cases), adenocarcinoma (6% of cases), prostatic intraepithelial neoplasia (4% of cases), stromal nodules of hyperplasia (4% of cases), and atypical adenomatous hyperplasia (4% of cases). A total of 3% of cases were inadequate. Majority of prostatic lesions were belonging to the 6th decade followed by the 7th decade. All cases of adenocarcinoma were belonging to the 6th decade. The test of prostatic-specific antigen was higher (more than 10 ng) in cases of adenocarcinoma. Conclusions: The study is conducted to see that combine approach of prostate-specific antigen and histopathological examination is useful for its recommendation, for better management of prostatic lesions in tertiary care center.