Diastolic Dysfunction in Patients with Metabolic Syndrome

ABSTRACT

Background The association of metabolic syndrome with the subclinical changes in the function and structure ofthe heart has been established clinically. Additionally, diastolic dysfunction and left ventricular hypertrophy werealso found to be closely associated with the metabolic syndrome. It has been identified in many of the previousstudies that LV dysfunction and LV hypertrophy are major risk factors of heart failure with preserved ejectionfraction.Aim The study was carried out to identify whether preclinical LV diastolic dysfunction can occur independent ofLV hypertrophy in MS or not.Methods 100 patients were taken for the study with 50 patients in the case group having MS and 50 patients inthe control group without MS. The patients who had any exiting cardiovascular disease including (heart failure,left ventricular ejection fraction [LVEF]<50%, coronary artery disease, or valvular heart disease were excluded fromthe study.Results The mean age of the case group was 45±8.5 years and that of the control group was 42±7.5 years therewas statistically significant difference among the various baseline characteristics between the case and controlgroups as the p value was found to be <0.05. All the ecocardioghraphic parameters had statistically significantdifference among the two groups except Left ventricular end diastolic dimension.Conclusion The study depicted a positive correlation between diastolic dysfunction and metabolic syndrome.Furthermore, it was observed in the study that metabolic syndrome proved to the baseline indicator of prognosisto diastolic dysfunction in the near future.