Radio-histopathological evaluation of anti-arthritic activity of apigenin in Freund’s induced arthritis in Wistar Albino Rats
Article
| IMSEAR
| ID: sea-217739
ABSTRACT
Background:
Arthritis is a leading cause of physical disability and impaired quality of life. At present, symptomatic treatment is available for arthritis. According to literature, apigenin possess anti-inflammatory activity. Aims andObjectives:
The present study aimed to screen the anti-inflammatory activity of Apigenin in freund’s induced arthritis in Wistar albino rats. Materials andMethods:
A total 30 rats were selected and divided into five groups each of six animals. Group – I (Normal saline), Group – II (Freund’s adjuvant (0.1 ml of 0.5%), Group – III (Dexamethasone 0.1 mg/kg), Group – IV (Apigenin 50 mg/kg), and Group – V (Apigenin 100 mg/kg) doses were administered to their respective groups for 28 days. X-ray was taken on 28th day and animals were sacrificed and affected paw used for histopathological examination.Results:
Group – II rats showed inflammation, thickness, fibro, and fatty changes in joint compared to Group – I X-ray and histopathological examination. Groups – III and V rats showed reduction inflammation, thickness, and fatty changes compared to Group – II. Group – IV showed lesser effect compared Group – V.Conclusion:
Apigenin administration significantly prevent the Freund’s induced radiological and histopathological changes in rats.
Full text:
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Index:
IMSEAR (South-East Asia)
Year:
2022
Type:
Article
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