EFFECT OF CURCUMIN AS AN ADJUNCT TO SCALING AND ROOT PLANING, AND ITS THERAPEUTIC EFFECT ON SALIVARY NITRIC OXIDE LEVELS IN PATIENTS WITH CHRONIC PERIODONTITIS - A CLINICO - BIOCHEMICAL STUDY.

ABSTRACT

Context (Background) Periodontitis is an infectious inflammatory disease with increase in salivary Nitric oxide levels and Curcumin is known to inhibit inflammatory mediators and neutralize nitric oxide which is expressed in salivary glands. To evaluate and compare the possible improvement in parameters of periodontal disease and salivaryAim: nitric oxide levels in patients undergoing scaling and root planing (SRP) alone and scaling and root planing (SRP) with systemic curcumin administration. In one group, systemic curcumin will be administered along withSettings & Design: SRP & in another group only SRP will be performed. In Group A, SRP along with systemicMethods & Materials curcumin was administered, and in Group B only SRP was performed. In both the groups, periodontal parameters such as the plaque Index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), presence or absence of bleeding on probing (BOP) and salivary nitric oxide (NO) levels by spectrophotometer were assessed at baseline and after three month. Chi-Square-test was used so as to evaluate and compare theStatistical Analysis used possible improvement in parameters of periodontal disease and salivary nitric oxide levels in patients undergoing scaling and root planing (SRP) alone and scaling and root planing (SRP) with systemic curcumin administration. Results & Conclusions: Clinically significant results with improvement in clinical parameters and reduction in salivary NO levels were noticed in both the groups, although test group showed more reduction in the salivary NO levels when compared to the control group thus concluding that administration of systemic curcumin is effective against salivary NO levels and can be used as an adjunct to SRP.