Serum Uric Acid as an Independent Risk Factor for Acute Ischemic Stroke

ABSTRACT

Serum Uric Acid as an Independent Risk Factor for Acute Ischemic StrokeBackground: Stroke is a neurological deficit due to acute focal injury of the central nervous system due to any vascular cause. The role of serum uric acid as a risk factor for acute stroke is an area of importance to many researchers. We in the current study tried to determine the levels of serum uric acid in cases of acute ischemic stroke and compare them with those in age and sex-matched controls. Methods: This hospital-based case-control study was performed in the Department of General Medicine, Prathima Ins?tute of Medical Sciences, Naganoor, Karimnagar. All the subjects were interviewed, examined, and inves?gated as per the predesigned and pre-tested proforma. Biochemical inves?ga?ons included es?ma?on of serum uric acid, serum triglycerides, fas?ng blood glucose, Renal func?on tests, and Liver func?on tests. Results: Mean Serum Uric Acid level was lower in the pa?ents with lacunar stroke as compared to the pa?ents with larger infarcts (6.16 ± 1.68 mg/dl vs. 6.73 ± 2.07 mg/dl). Bu?hisdifference was not sta?s?cally significant as the p-value is >0.05.The correla?on between SUA and NIHSS score was studied with the help of Spearman rank correla?on. It was found that there was a significant posi?ve correla?on between SUA and NIH stroke scale score on admission as well as at the ?me of discharge (p<0.05 for both). Conclusion: Elevated serum uric acid level is independently associated with acute ischemic stroke. It was observed that serum uric acid levels were correlated with hypertension, diabetes mellitus, smoking, obesity, and metabolic syndrome. It was found that cases with elevated serum acid levels had poor prognosis and overall mortality rate.