Allergic Drug Reactions: How Do The Dermatologists Of Vadodara City Perceive And Contribute To Pharmacovigilance Program?

ABSTRACT

Background:The pharmacovigilanceisimperativein defining safety profile of the drug.As cutaneous Adverse Drug Reactions (ADRs) are very common, dermatologists’ contribution to pharmacovigilanceprogram of India (PvPI) is important. This study was conducted to know dermatologists’ perception about ADRs; their awareness and participation inPvPI. Material and Methods:A Prospective, cross-sectionalsurvey was conductedamongst dermatologists, approaching via Whatsappor during academic meetings. Pre-validated questionnaire including their demographic details, perception of risk of allergic reactions, awareness of PvPI and ADRs reporting was utilized. Data analysis was done with Microsoft Excel and Graph Pad prism software. Results:Out of 73 dermatologists, 44 responded the survey (Coverage rate 60%).Highest and lowest risk amongstantimicrobials for ADRswas perceived for sulphonamides and cephalosporins respectively. Amongstnon-antimicrobials, it was Non-steroidal anti-inflammatory drugs (NSAIDs) and local anaesthetics respectively. Awareness about PvPI was seen in 94% and 38% of dermatologists working in an institute and in a private set up respectively. Amongst them, 78% and 18% had ever reported ADRs to PvPI. Conclusions:Sulphonamides and NSAIDs were perceived to have higher risk ofADRs. Limited number of dermatologists have contributed to national ADR database amongst the ones who are aware of PvPI.