Prevalence of Cardiotoxicity Induced by Chemotherapy Measured by Dobutamine Stress Echocardiogram (DSE) in BSMMU

ABSTRACT

Background: Cardiotoxicity related to cancer treatment is an alarming source of significant morbidity and mortality, and may differ from subclinical myocardial dysfunction to irreversible heart failure or even death. DSE is a safe, feasible, and accurate modality for finding of myocardial ischemia and prognostication in patients with known or suspected coronary artery disease, particularly when they have limited exercise capacity.Materials& Methods:This study is a cross-sectional observational study which was conducted at the department of Cardiology, in BSMMU, Dhaka from June 2019- December 2019. The sample size for this study was 50.Results:The mean age was 56� where 17(34%) of the respondents were <65 years and 33(66%) were >65 years. The male respondent was 35(70%) where female was 15(30%). Diabetes was found in 3(6%) cases and followed by Acute ischemia, Hypertension 6(12%), Coronary Artery Disease (CAD) 4(8%), ACE-inhibitors 5(10%), Beta-blockers 3(6%), Nitrates 3(6%). Acute leukemia was found in 13(26%). in M12-18 was 45�and followed by mean of LVESD (mm) was 27� 29� 29� 30� 30� 31� Mean of IVSd (mm) was 9� 9� 9� 9� 8� 8� Mean of Peak E (cm/s) was 80�, 76�, 74�, 73�, 66� 63� and the p-value was seen <0.001 which denotes a significant improvement in treatment (p<0.005).Conclusions:The early discovery of cardiotoxicity may ensure the improved chemotherapeutic process and timely management of the treatment of cardiomyopathy, such as beta-blockers and ACE inhibitors.