Assessment of Dyslipidemia in Ischemic and Hemorrhagic Stroke in Western Uttar Pradesh

ABSTRACT

Background: Stroke is one of the major global health problems and the leading cause of adult disability. This study was carried out to compare serum lipid profiles in patients with ischaemic and haemorrhagic stroke.Material & Methods:We conducted this study on 130 patients of 18-70-year age group with clinically and radiologically (CT Scan ) proven cerebrovascular accident. Detailed clinical evaluation was combined with biochemical and radiological evaluation.Results:76 patients were diagnosed to have ischaemic stroke while 54 had haemorrhagic stroke, showing that ischaemic stroke is more common, being 58.46% when compared to haemorrhagic stroke, which was 41.54%.The mean age for ischaemic stroke was 63.32 years while for haemorrhagic stroke was 58.87 years. Patients were evaluated according to gender and it was found that both ischaemic and haemorrhagic stroke is more common among males. It was found that 30.3% of patients with ischaemic stroke were diabetic while 18.5% of haemorrhagic stroke patients had diabetes. 48.7% of ischaemic stroke patients and 81.5% of haemorrhagic stroke patients had hypertension. It was found that smoking was associated with 51.3% in patients with ischaemic stroke and 40.7% in haemorrhagic stroke. Serum total cholesterol was significantly higher in ischaemic stroke than haemorrhagic stroke group. Mean value of s. HDL cholesterol was 40.24 mg/dl in ischaemic stroke group, 44.98 mg/dl in haemorrhagic stroke group showing s. HDL cholesterol was significantly lower in ischaemic stroke group. Thus, hypercholesterolemia is significantly more associated with ischaemic strokes. Our study showed that s. triglyceride was significantly higher in ischaemic stroke than haemorrhagic stroke group. Our study also shows that s. LDL cholesterol was significantly higher in ischaemic stroke group.Conclusions:Ischaemic stroke patients had higher serum total cholesterol, higher S. LDL cholesterol and lower HDL-cholesterol levels in comparison to haemorrhagic stroke. High risk patients of stroke may be screened using serum lipid profile and further studies are suggested to evaluate the effect of lipid lowering therapy in terms of morbidity and mortality in ischaemic stroke patients.