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Secondary immune defects in non-Hodgkin's lymphoma.
Datta, U; Kaur, K; Varma, S C; Bhaskar, K V; Sehgal, S.
Article in English | IMSEAR | ID: sea-22045
ABSTRACT
Changes in the humoral, cellular and phagocytic components of the immune system were investigated in 44 biopsy proven, untreated patients of non-Hodgkin's lymphoma (NHL). There was significant decrease in the total lymphocyte number, their subsets (T and B) and the T helper (T mu) population. Impaired leukocyte migration inhibition response and DNA synthesis following stimulation by phytohaemagglutinin were noted. Significant reduction of serum IgA was found in patients of both diffuse and nodular NHL. Phagocytic activity and nitroblue tetrazolium (NBT) reduction were unaltered, but chemotaxis was significantly reduced and bactericidal activity showed variable results.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Lymphoma, Non-Hodgkin / Humans / Immunoglobulin A / Immunoglobulin G / Immunoglobulin M / Lymphocyte Subsets / Immunity, Cellular / Leukocyte Count / Antibody Formation / Neutrophils Language: English Year: 1992 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Lymphoma, Non-Hodgkin / Humans / Immunoglobulin A / Immunoglobulin G / Immunoglobulin M / Lymphocyte Subsets / Immunity, Cellular / Leukocyte Count / Antibody Formation / Neutrophils Language: English Year: 1992 Type: Article