ClinicalManifestations ofSteven'sJohnson Syndrome/Toxic Epidermal Necrolysis

ABSTRACT

BACKGROUND: Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) both reflect extreme manifestations of the same clinical entity responsible for significant, life Threatening hypersensitivity mucocutaneous reactions, caused by intraepidermal cell death resulting in epidermal sloughing and blistering; often induced by medications. The mucous membranes of the mouth, stomach, lungs,skin, and genitourinary system are all major sites of Involvement. Despite receiving effective treatment at the local and systemic levels, some survivors may have major ocular consequences that might ultimately result in blindness. It is still unknown whether or not SJS/TEN can be effectively treated locally or systemically. If you want to improve your long-term eye health, it's crucial to catch any problems early and treat them aggressively. Chronic ocular surface failure, including a lack of limbal cells and full keratinization of the ocular surface, may be detected by inspecting the eyelid edge,palpebral conjunctiva, and fornix. It is possible to lessen the danger of ocular surface failure using transplants of amniotic membrane or a cultured oralmucosal graft. AIM: The aim of this investigation is to learn more about the symptoms of SJS/TEN that emerge in the eyes. METHODOLOGY: Patients with ocular signs of SJS/TEN who sought treatment at C.U.Shah medical college and hospital, a tertiary hospital, via the OPD and IPD of skin and VD were included. Between January 2022 and May 2022, all patients had a documented ophthalmologic evaluation. RESULTS: The study had 17 participants. Ocular involvement was seen in 10 individuals, with 5 patients (50%) experiencing mild ocular indications, 2 patients (20%) experiencing moderate visual manifestations, and 3 patients (30%) experiencingsevere ocular signs. Two patients (20%) had involvement of the cornea, seven patients (70%) had involvement of the conjunctiva, and six