Seroprevalence of Hepatitis C Virus in Liver Disease Patients and Blood Donors from Northern India
Article
| IMSEAR
| ID: sea-221060
ABSTRACT
Background:
The molecular epidemiology of HCV and its association with liver diseases in North India is not well understood.Aim:
To assess the incidence of HCV infection in blood donors and liver disease patients and the influence of HCV genotype on the severity of the liver disease.Methods:
We screened 487 patients with acute viral hepatitis (AVH), 141 patients of fulminant hepatic failure(FHF), 1058 patients of chronic liver disease (CLD) (chronic hepatitis-468, cirrhosis-527, HCC-63), and 3504 voluntary blood donors for anti-HCV. Anti HCV positive patients were further subjected to HCV RNA testing followed by genotyping.Results:
HCV infection was observed in 1.6%, 12.94%, 10.64%, 27.13%, 21.25% and 49.2% of blood donors, AVH,FHF, chronic hepatitis, cirrhosis and HCC patients respectively.Conclusion:
Genotype 3 was found to be the major genotype. HCV genotype one infection was associated with advanced liver disease.
Full text:
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Index:
IMSEAR (South-East Asia)
Year:
2021
Type:
Article
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