ASSOCIATION BETWEEN C-REACTIVE PROTEIN AND GLYCOSYLATED HEMOGLOBIN IN TYPE-2 DIABETES MELLITUS: AN INDIAN PERSPECTIVE

ABSTRACT

Background: Diabetes mellitus (DM) is a complex metabolic disorder that alters the glucose status of the human body. There has been a steady increase in the prevalence of DM in the past few decades leading to macro-and microvascular complications. There has been mounting evidence suggesting that in?ammation plays a role in the pathophysiology of DM. Methods: Asingle centre prospective study was conducted on 50 consecutive patients with de novo or prior Type-2 DM (T2DM) history between JANUARY 2021 to OCTOBER 2021. CRP and HbA1c samples were taken at the start of the study and were retaken after 12 weeks of pharmacotherapy and lifestyle modification. The relationship between CRPand HbA1c was analysed. Results: The mean HbA1c and CRP for the initial 50 participants were 9.6500 ± 1.8816 and 1.1520 ± 0.9984, respectively. At the 12th-week follow up, the mean HbA1c fell to 7.3952 ± 1.3155 (P<0.05), and the mean CRP was reduced to 0.2857 ± 0.5237 (P<0.05). Furthermore, the rise in HbA1c was correlated with a statistically signiflcant rise in CRP. Conclusion: This study establishes a positive correlation between serum CRP and HbA1c. Improving glycemic control can help reduce the risk of adverse events associated with sustained inflammation