HLA antigen pattern of Kashmiri patients with rheumatic heart disease.
Article
in English
| IMSEAR
| ID: sea-22166
ABSTRACT
The distribution of HLA class-I (A, B and C), and class II (DR and DQ) antigens was studied in 50 randomly selected Kashmiri Muslim patients with established rheumatic heart disease and compared with that of 50 controls of similar ethnicity. A significant increase in the frequency of HLA-DR4 (P < 0.005, RR 3.27) and a significant decrease in the frequency of HLA-B5 (P < 0.001, RR 0.19) were found in the patient group. Though HLA-DQ3 showed a significant increase (P < 0.005, RR 2.52) and HLA-DR7 a significant decrease (P < 0.05, RR 0.42) in the patient group, the corrected P value was not significant. The findings suggest that susceptibility to RHD in the studied population is HLA-related, with HLA-DR4 influencing its occurrence and HLA-B5 conferring protection against the same.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rheumatic Heart Disease
/
Female
/
Humans
/
Male
/
Case-Control Studies
/
Adolescent
/
Adult
/
HLA Antigens
/
India
/
Islam
Type of study:
Observational study
Country/Region as subject:
Asia
Language:
English
Year:
1997
Type:
Article
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