Surfactant protein-A levels in patients with acute respiratory distress syndrome.
Article
in English
| IMSEAR
| ID: sea-22457
ABSTRACT
BACKGROUND & OBJECTIVES:
The decrease in surfactant protein-A (SP-A level) has recently been implicated in the pathophysiology of acute respiratory distress syndrome (ARDS). Mechanical ventilation is the main modality of treatment of ARDS. But information on the SP-A levels after mechanical ventilation is scanty. We therefore studied the effect of mechanical ventilation on SP-A levels in patients with ARDS.METHODS:
In a prospective, observational study conducted in the Respiratory Intensive Care Unit of a tertiary care hospital in north India, 13 patients with ARDS requiring mechanical ventilation were included. SP-A levels in the bronchial aspirates were serially estimated by ELISA at the start of mechanical ventilation and after 24 and after 48 h.RESULTS:
The SP-A level at the start of mechanical ventilation was 3.06 +/- 2.56 microg/ml. The levels gradually increased to 3.99 +/- 2.39 and 6.64 +/- 2.72 microg/ml, at 24 and 48 h respectively, and this increase was statistically significant (P < 0.05). Patients having an infectious etiology had lower SP-A levels compared to those with non-infections causes. Neither the initial SP-A level nor the increase in SP-A level correlated with the improvement in lung function or duration of ventilation. INTERPRETAION &CONCLUSION:
The present study showed a progressive increase in the SP-A levels in patients with ARDS on mechanical ventilation. Further studies are required to confirm that the increase in SP-A levels may be one of the contributors for recovery in ARDS.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pneumonia
/
Respiratory Distress Syndrome
/
Bronchi
/
Female
/
Humans
/
Male
/
Enzyme-Linked Immunosorbent Assay
/
Acute Disease
/
Prospective Studies
/
Adolescent
Type of study:
Observational study
Language:
English
Year:
2003
Type:
Article
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