Effect of Maternal Supplementation With Two Different Doses of Vitamin D During Lactation on Vitamin D Status, Anthropometry and Bone Mass of Infants: A Randomized Controlled Trial
Indian Pediatr
;
2022 Apr; 59(4): 276-282
Article
| IMSEAR
| ID: sea-225316
ABSTRACT
Background:
There is a high prevalence of vitamin D deficiency (VDD) in exclusively breast-fed infants in the absence of appropriate vitamin D supplementation.Objective:
To evaluate the efficacy of two doses of maternal vitamin D supplementation on vitamin D levels of mother-infant pairs and to assess its effect on growth parameters (weight, length and head circumference) and bone mass of infants. Studydesign:
Randomized controlled trial.Participants:
Lactating mother-infant pairs (n=220). Intervention Maternal oral vitamin D supplementation in two doses (group 1 1,20,000 IU/month and group 2 12,000 IU/month) for 12 months. Mainoutcomes:
Maternal and infant serum 25OHD levels, and infants’ growth and bone mass.Results:
There was high prevalence of VDD at baseline in mothers (94%) as well as infants (98.5%), which was reduced to 43.1% in (mothers) and 46.5% in infants after 12 months. Significantly higher median (IQR) serum 25OHD levels (ng/mL) were observed among mothers in group 1 compared to group 2 [46 (17-159) vs 18 (6-64); P<0.01] and in infants [36.5 (15-160) vs 17 (7-32); P<0.01]. No significant association was observed between growth parameters or bone mass and serum 25OHD levels of mother or infant between the two groups. Four mothers (3.6%) and two infants (1.8%) in group I had serum 25OHD>100 ng/mL, but without hypercalciuria or hypercalcemia.Conclusion:
Bolus vitamin D supplementation in the dose of 1,20,000 IU/month was more efficacious in improving maternal and infant vitamin D status at 12 months, as compared to 12,000 IU/month.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Journal:
Indian Pediatr
Year:
2022
Type:
Article
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