Immune response to purified chick embryo cell culture rabies vaccine (Rabipur) in dog-bite victims.

ABSTRACT

The immunogenic and protective efficacy of a new, killed and purified rabies virus vaccine prepared in chick embryo fibroblast cell culture, has been evaluated. Vaccine was administered on days 0, 3, 7, 14, 30 and 90 to 29 subjects who were bitten by dogs. Persons bitten on the face, neck or hand were also given rabies immunoglobulin. Virus neutralizing antibody was measured on serially collected sera. On day 14, all 26 subjects who were tested had developed protective levels of antibody. High levels of antibody were maintained through day 105. No adverse reactions to the vaccine was reported by the subjects.