Assessment of rifampicin resistance in re-treatment cases of pulmonary tuberculosis using gene-xpert

ABSTRACT

Objective:To assess therifampicin resistance in re-treatment cases of pulmonary tuberculosis using gene-xpert.Material and methods:This cross sectional study was conducted at Department of Pulmonology Bahawal Victoria Hospital, Bahawalpur.Total 145 patients who came for re-treatment of TB either male or female having age 20-60 years were selected for this study.Results:Mean age of the patients was 45.79 ± 11.65 years and mean duration of TB was 5.44 ± 2.9 years.Rifampicin resistance was found in 55 (38%) cases by using gene-xpert test. Rifampicin resistance is significantly associated with gender but insignificantly associated with age and duration of TB.Conclusion:In present study very high percentage of rifampicin resistance was found in retreatment cases of TB by using gen-xpert test.Significant association of gender with rifampicin resistance was noted but insignificant association of age and duration of TB with rifampicin resistance was detected.