Production and optimization studies of cephalosporin C by solid state fermentation.
Hindustan Antibiot Bull
;
2002 Feb-Nov; 44(1-4): 1-7
Article
in English
| IMSEAR
| ID: sea-2315
ABSTRACT
Production of cephalosporin C employing a strain, Cephalosporium sp. NCIM 1039 under solid state fermentation was optimized. Different substrates like wheat bran, wheat grains, rice grains, barley and rice bran were studied to optimize the best substrate. Wheat bran showed the highest antibiotic yield. The physical and chemical parameters were optimized. The maximum productivity of cephalosporin C (750 U/g) was achieved by employing wheat bran and with optimized nutritional and process parameters such as potato starch as additive 1% w/w, urea as additive 1% w/w, incubation period of 7 days, incubation temperature at 30 degrees C, inoculum level 10% w/v, moisture content of solid substrate 80% and pH 7.0.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Acremonium
/
Cephalosporins
/
Culture Media
/
Fermentation
/
Hydrogen-Ion Concentration
Language:
English
Journal:
Hindustan Antibiot Bull
Year:
2002
Type:
Article
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