Prediabetes, dyslipidemia and c-reactive protein levels among stroke patients: a hospital-based study in north-east India

Background: Stroke is defined as an abrupt onset of a neurologic deficit lasting for more than 24 hours that is attributable to a focal vascular cause. Hyperglycemia and dyslipidemia are often documented in stroke patients. Elevated CRP level is independently associated with the excessive risk of ischemic stroke. Aim and Objectives were to evaluate the glycemic status, lipid profile and c-reactive protein level in stroke patients admitted in a teaching institute of north-east India. Methods: A cross-sectional hospital-based study conducted in the department of medicine, Agartala Government Medical College and GBP hospital, within a period of January 2020 to June 2021. Data were analyzed by SPSS software version 15 using appropriate statistical tests. Results: Among 200 patients of stroke, 50% was found to be pre-diabetic, 40% known diabetic and 10% newly diagnosed diabetic. 60% were hypertensives. Among them, 80% had ischaemic stroke and 20% hemorrhagic stroke. 70% of the patients had hypercholesterolemia, 60% had hypertriglyceridemia. 80% had raised serum LDL and 57% decreased serum HDL. Out of 200 patients, 60% was found to have raised serum CRP level. 55% of ischaemic stroke patients and 5% of hemorrhagic stroke patients had raised CRP level. Conclusions: Prediabetes and newly diagnosed diabetes are highly prevalent in patients with stroke or TIA. As the prevalence of prediabetes is growing rapidly, prediabetes might become one of the most important modifiable therapeutic targets in both primary and secondary prevention. Early detection of dyslipidemia and treatment with drugs along with dietary modifications and lifestyle changes can reduce the risk of stroke. Since, it was a cross-sectional study, these results need to be validated by further long-term prospective studies.