Hepatoprotective effect of rhinax on antitubercular drug-induced hepato-toxicity in rats.
Hindustan Antibiot Bull
;
2002 Feb-Nov; 44(1-4): 53-9
Article
in English
| IMSEAR
| ID: sea-2339
ABSTRACT
Rhinax, a polyherbal formulation, exhibited hepatoprotective function when tested against antitubercular drug-induced hepatotoxicity in rats. Suppression of GSH and antioxidant enzymes "superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), gultathionle peroxidase (GPx) and glutathione S-transferase (GST) were noticed in the liver of antitubercular chemotherapeutic agents (namely isoniazid, rifampicin and pyrazinamide) treated animals accompanied with an increase in cytochrome P-450 contents and increased production of lipid peroxidation. Rhinax afforded hepatoprotection by inhibiting lipid peroxidation and, as a result, the animals showed improved antioxidant status.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Male
/
Plant Extracts
/
Lipid Peroxidation
/
Rats, Wistar
/
Herbal Medicine
/
Chemical and Drug Induced Liver Injury
/
Liver
/
Liver Function Tests
/
Animals
Language:
English
Journal:
Hindustan Antibiot Bull
Year:
2002
Type:
Article
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