Experimental studies on membrane permeability defects of drug-resistant bacteria.
Article
in English
| IMSEAR
| ID: sea-23675
ABSTRACT
Multiply antibiotic-, lysozyme-and bacitracin-resistant, representative strains of staphylococci, Escherichia coli, Shigella dysenteriae and Klebsiella pneumoniae were compared respectively with their parent cultures in respect of their membrane permeability as judged by fluorescence polarization spectroscopy, using a sensitive fluorescent probe. The cytoplasmic membrane of the drug-resistant mutants was found to be less fluid and permeable, compared to that from the sensitive wild types. The study constitutes an attempt to determine the physical basis for the mechanism of resistance of certain bacteria against certain drugs.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Temperature
/
Bacitracin
/
Bacteria
/
Drug Resistance, Microbial
/
Muramidase
/
Cell Membrane Permeability
/
Bacterial Physiological Phenomena
/
Mutation
Language:
English
Year:
1989
Type:
Article
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