Hepatoprotective activity of silymarin against hepatic damage in Mastomys natalensis infected with Plasmodium berghei.
Article
in English
| IMSEAR
| ID: sea-23926
ABSTRACT
Silymarin, a flavolignan from the seeds of Silybum marianum, showed significant hepatoprotective activity in P. berghei-induced hepatic damage in M. natalensis, as assessed by changes in several serum and liver biochemical parameters. Changes in lipoprotein-X, GOT, GPT, alkaline phosphatase and bilirubin were found to be protected by silymarin at different doses. Maximum activity was observed at a dose of 5 mg/kg bw, po. Silymarin had no effect on parasitaemia.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plasmodium berghei
/
Silymarin
/
Flavonoids
/
Male
/
Disease Models, Animal
/
Dose-Response Relationship, Drug
/
Hepatitis, Animal
/
Liver Function Tests
/
Animals
/
Malaria
Language:
English
Year:
1989
Type:
Article
Similar
MEDLINE
...
LILACS
LIS