Association of angiotensin converting enzyme (ACE) gene polymorphism with hypertension in a Bangladeshi population.
Bangladesh Med Res Counc Bull
;
1998 Dec; 24(3): 55-9
Article
in English
| IMSEAR
| ID: sea-244
ABSTRACT
The association of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with hypertension has not been confirmed. Inconsistencies may be due to the differences of background population characteristics. Till date, there has been no report in Bangladeshi population. This study was to examine the association of ACE (I/D) polymorphism with hypertension. Fifty-one primary hypertensives and fifty-two normotensives were recruited from a hospital in Dhaka city. Height, weight and blood pressure were measured. ACE (I/D) genotypes was established using polymerase chain reaction protocol. The genotype and allele frequencies did not differ significantly (P > 0.05) between the groups. In logistic regression analysis, adjusted for age, sex and body mass index, the genotypes were not associated with hypertension (DD vs II Adds ratio = 2.6, P = 0.34; ID vs II 0.4, 0.23; ID + DD vs II 0.8, 0.69). In this hospital-based sample of Bangladeshi people, significant association of ACE I/D genotype with hypertension was not observed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polymorphism, Genetic
/
Bangladesh
/
Female
/
Humans
/
Male
/
Case-Control Studies
/
Logistic Models
/
Polymerase Chain Reaction
/
Peptidyl-Dipeptidase A
/
Adult
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Bangladesh Med Res Counc Bull
Year:
1998
Type:
Article
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