Involvement of adrenergic & cholinergic mechanisms in analgesia electrically induced from pretectal nucleus of rat.
Article
in English
| IMSEAR
| ID: sea-25422
ABSTRACT
Analgesia induced by pretectal stimulation in rat was analysed using suitable antagonists. Mild electrical stimulation of sites in the pretectal nucleus (PTN) caused analgesia of long duration, without signs of aversion and unassociated with motor deficit. Pretreatment of animals with ip atropine sulphate (1 mg/kg), phenoxybenzamine (5 mg/kg), sotalol (2 mg/kg) and haloperidol (1 mg/kg) but not with saline, markedly reduced the antinociceptive response to PTN stimulation. Mild PTN stimulation thus seems to induce potent and long lasting analgesia in rats probably involving multisynaptic antinociceptive pathway(s).
Full text:
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Index:
IMSEAR (South-East Asia)
Main subject:
Phenoxybenzamine
/
Rats
/
Atropine
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Sotalol
/
Tail
/
Male
/
Tectum Mesencephali
/
Neurotransmitter Agents
/
Electric Stimulation
/
Haloperidol
Language:
English
Year:
1991
Type:
Article
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