Effect of Gamiseunggal-Tang on immediate type allergic reaction in mice.
Article
in English
| IMSEAR
| ID: sea-25622
ABSTRACT
BACKGROUND & OBJECTIVE:
The herbal formulation, Gamiseunggal-Tang (G-Tang) has long been used for various allergic diseases. The mechanism of its action is largely unknown. We carried out this study to determine the effect of G-Tang on the mast cell-mediated anaphylactic reactions in vivo and in vitro murine models.METHODS:
In this study, the effects of G-Tang on the mast cell-mediated anaphylactic reactions were examined by using the ear swelling, histamine assay, and ELISA method in murine model.RESULTS:
Anal administration of G-Tang showed dose-dependent inhibitory activity on the compound 48/80-induced ear swelling response (P<0.05) and histamine release (P<0.01). G-Tang (0.001-0.1 g/kg) significantly inhibited passive cutaneous anaphylaxis (P<0.05) in mice. The production of tumour necrosis factor-alpha (TNF-alpha) was also significantly inhibited (about 47.4%, at 0.1 mg/ml, P<0.01) by treatment of G-tang in anti-dinitrophenyl IgE antibodystimulated mast cells. INTERPRETATION &CONCLUSION:
Findings of our study showed that G-Tang inhibited immediate type allergic reaction in a murine model and may be beneficial in the treatment of allergic inflammatory diseases.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Humans
/
Immunoglobulin E
/
Plant Extracts
/
Cells, Cultured
/
Tumor Necrosis Factor-alpha
/
Rats, Wistar
/
P-Methoxy-N-methylphenethylamine
/
Dinitrophenols
/
Ear
Type of study:
Prognostic study
Country/Region as subject:
Asia
Language:
English
Year:
2007
Type:
Article
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