Stimulation of the absorption of macromolecules in Giardia lamblia infected mice intestine.
Article
in English
| IMSEAR
| ID: sea-25648
ABSTRACT
The absorption of 125I-labelled bovine serum albumin, gamma-globulin and alpha-lactalbumin was considerably enhanced in G. lamblia infected Swiss mice intestine compared to uninfected controls. The binding of 125I-proteins to brush border membrane was however, significantly (P less than 0.01) low in infected animals. Kinetic studies with gamma-globulin binding to brush borders revealed a decrease in the number of binding sites in infected animals (1.52) compared to controls (2.86 micrograms/mg protein) with no change in the affinity constant (47.60 micrograms/ml) under these conditions. These findings suggest that G. lamblia infection in mice leads to enhanced macromolecular absorption which seems unrelated to the binding of proteins to epithelial cell surface.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Male
/
Gamma-Globulins
/
Serum Albumin, Bovine
/
Giardiasis
/
Disease Models, Animal
/
Intestinal Absorption
/
Lactalbumin
/
Animals
/
Mice
Type of study:
Prognostic study
Language:
English
Year:
1990
Type:
Article
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