Auto antibodies to nucleosides in systemic lupus erythematosus.
Article
in English
| IMSEAR
| ID: sea-25684
ABSTRACT
Serological studies in 110 patients with systemic lupus erythematosus (SLE) have shown that autoantibodies to DNA and RNA had subspecificity to adenosine (30.9%), cytidine (79%), guanosine (44.5%), thymidine (20%) and uracil (56.3%). It was also observed that DNA antibodies are heterogenous and that antibody with specificity for both the native confirmation as well as exposed nucleoside of the denatured molecule were present in sera of most of the patients with SLE. There was also alteration in the pattern of antibody to nucleoside in some patients who were treated with steroids or immunosuppressive drugs.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Autoantibodies
/
Humans
/
DNA
/
RNA
/
Lupus Erythematosus, Systemic
/
Antibody Specificity
/
Nucleosides
Language:
English
Year:
1990
Type:
Article
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