A flowcytometric study of CD4+ & CD19+ cell lymphopenia in patients with alopecia areata.
Article
in English
| IMSEAR
| ID: sea-26033
ABSTRACT
Twenty five patients with alopecia areata and 20 healthy controls were studied by flowcytometry employing direct two colour immunofluorescence in erythrocyte lysed whole blood. A significant reduction was observed in helper/inducer (CD4+) lymphocytes (29.4 +/- 7.4 vs 39.45 +/- 8.0, P < 0.01) and B (CD 19+) lymphocytes (11.04 +/- 6.57 vs 15.0 +/- 5.05, P < 0.01) in comparison with healthy controls. Decrease in T-lymphocytes (CD3+) and suppressor/cytotoxic (CD8+) was not significant and activated (HLADR+) lymphocytes and natural killer cells (CD16+ and CD56+) were within normal limits. Our findings suggest a significant T helper (CD4+) and B (CD19+) cell lymphopenia in alopecia areata.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
CD4 Antigens
/
Case-Control Studies
/
Child
/
Child, Preschool
/
Adolescent
/
Antigens, CD19
/
Adult
Type of study:
Observational study
Language:
English
Year:
1996
Type:
Article
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