Effect of aspirin on isoproterenol induced changes in lipid metabolism in rats.
Article
in English
| IMSEAR
| ID: sea-26156
ABSTRACT
The effect of aspirin on isoproterenol induced changes in lipid metabolism in rats was studied. Aspirin (1.2 mg/100 g/day) was administered orally for a period of 60 days along with/without isoproterenol (20 mg/100g sc twice at a time interval of 24 h for 2 days). Isoproterenol treated rats showed an increase in the levels of heart cholesterol, triglycerides and free fatty acids. The activity of cholesterol ester synthetase CES was increased significantly with concomitant increase in heart lipid peroxide levels in isoproterenol treatment. Aspirin treatment could restore the enzyme activity to near normal and also reduce the level of lipid peroxides. The lipid changes were minimum in rats treated with aspirin and isoproterenol.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Triglycerides
/
Male
/
Aspirin
/
Cholesterol
/
Sterol Esterase
/
Administration, Oral
/
Rats, Wistar
/
Lipid Metabolism
/
Fatty Acids, Nonesterified
Language:
English
Year:
1993
Type:
Article
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