Inhibition of two HMP shunt pathway enzymes by fatty acids and their CoA esters in developing human brain: role of fatty acid binding protein.
Indian J Biochem Biophys
;
1994 Dec; 31(6): 464-8
Article
in English
| IMSEAR
| ID: sea-26350
ABSTRACT
Inhibitory effects of fatty acids and their CoA esters on glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities of human fetal brain cytosol have been studied. Purified human fetal brain fatty acid binding protein reverses the inhibitory effects of palmitoyl-CoA and oleic acid on glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase activities in human fetal brain cytosol. This protein, when added alone, activates the enzymes. Levels of fatty acid binding proteins as well as the activities of these two HMP shunt pathway enzymes, which provide cofactors like NADPH for reductive biosynthesis, increase with gestation. These results indicate that a relationship exists between the high demand for fatty acids and synthesis of cofactors for lipid biosynthesis in developing brain.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pentose Phosphate Pathway
/
Phosphogluconate Dehydrogenase
/
Humans
/
Acyl Coenzyme A
/
Carrier Proteins
/
Tumor Suppressor Proteins
/
Esters
/
Fatty Acid-Binding Proteins
/
Fatty Acids
/
Embryonic and Fetal Development
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1994
Type:
Article
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