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Interaction of chlorpromazine with hemoglobin.
Indian J Biochem Biophys ; 1990 Aug; 27(4): 240-4
Article in English | IMSEAR | ID: sea-26377
ABSTRACT
Binding of chlorpromazine (CPZ), a widely used antidepressant tranquilizer, with hemoglobin has been studied by equilibrium dialysis method. r/Cf versus r plot was typically concave downwards revealing the positive cooperative nature of binding. Binding parameters, namely the affinity constant (K) and the degree of cooperativity (nH) were determined from the Hill plot. Oxygen was found to be released gradually from hemoglobin with gradual addition of CPZ, the extent of oxygen release depending on the stoichiometric ratio of CPZ hemoglobin (D/P).
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Oxygen / Binding Sites / Humans / Hemoglobins / Kinetics / Chlorpromazine Language: English Journal: Indian J Biochem Biophys Year: 1990 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Oxygen / Binding Sites / Humans / Hemoglobins / Kinetics / Chlorpromazine Language: English Journal: Indian J Biochem Biophys Year: 1990 Type: Article