Effect of chlorpromazine and gossypol on Ca(2+)-ATPase activity in the microsomal membranes of rat testes.
Indian J Biochem Biophys
;
1991 Apr; 28(2): 136-9
Article
in English
| IMSEAR
| ID: sea-26495
ABSTRACT
The microsomal membranes isolated from rat testes have been found to contain a Mg(2+)-dependent and a Mg(2+)-independent Ca(2+)-ATPase. The enzyme activities were inhibited by two contraceptive drugs--gossypol and chlorpromazine. The inhibition by the former was affected by the presence of ligand(s) and not the substrate in the incubation medium, whereas ligand(s)/substrate did not affect the inhibition by chlorpromazine. This may be explained from the fact that the binding of chlorpromazine and ligand(s)/substrate to the enzyme are independent of each other whereas in case of gossypol the ligand(s) compete with the drug at the binding site of the enzyme.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Testis
/
Male
/
Gossypol
/
Kinetics
/
Chlorpromazine
/
Ca(2/) Mg(2/)-ATPase
/
Calcium-Transporting ATPases
/
Intracellular Membranes
/
Animals
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1991
Type:
Article
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