Further characterization of negative regulatory element involved in the hormonal regulation of GlcNAc-1-P transferase gene in mouse mammary gland.
Indian J Biochem Biophys
;
1997 Feb-Apr; 34(1-2): 110-7
Article
in English
| IMSEAR
| ID: sea-26880
ABSTRACT
The gene encoding UDP-GlcNAcdolichol phosphate N-acetylglucosamine-1-phosphate transferase (GPT), the enzyme that initiates the pathway for the biosynthesis of asparagine-linked glycoproteins, is ubiquitously expressed in eukaryotic cells. However, its expression in the mammary gland is developmentally and hormonally regulated; transcription of the mouse mammary GPT gene is stimulated by the lactogenic hormones, insulin, glucocorticoid, and prolactin. Earlier, we demonstrated that a distal negative regulatory element in mouse GPT (mGPT) promoter plays an important role in developmental and hormonal control of mGPT gene expression in mammary gland (Ma J, Saito H, Oka T and Vijay IK (1996) J Biol Chem, in press). In this report, a tissue distribution of the repressor that binds the negative regulatory element was examined; a comparison of the negative regulatory element to other consensus sequences for known transcription factors is discussed.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Oligodeoxyribonucleotides
/
Repressor Proteins
/
Female
/
Base Sequence
/
Gene Expression Regulation, Enzymologic
/
Genes, Regulator
/
Promoter Regions, Genetic
/
Transferases (Other Substituted Phosphate Groups)
/
Animals
/
Mammary Glands, Animal
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1997
Type:
Article
Similar
MEDLINE
...
LILACS
LIS