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Polyene antibiotics in the membrane environment.
Indian J Biochem Biophys ; 1991 Aug; 28(4): 227-32
Article in English | IMSEAR | ID: sea-26901
ABSTRACT
The cytotoxic activity of the polyene antibiotics mainly depends on the appearance of the drug species which arises from drug-sterol complexation. The unsaturation and intact macrolide ring of the polyenes are the requirements for the biological activity. All the polyene antibiotics can form the complex with the sterol having 3 beta-OH group, and planar ring and a hydrophobic side chain. Aromatic polyene antibiotics with positively charged head group have been considered as most potential antifungal agents.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Sterols / Structure-Activity Relationship / Drug Carriers / Amphotericin B / Filipin / Liposomes / Animals / Membrane Lipids / Anti-Bacterial Agents Language: English Journal: Indian J Biochem Biophys Year: 1991 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Sterols / Structure-Activity Relationship / Drug Carriers / Amphotericin B / Filipin / Liposomes / Animals / Membrane Lipids / Anti-Bacterial Agents Language: English Journal: Indian J Biochem Biophys Year: 1991 Type: Article