Polyene antibiotics in the membrane environment.
Indian J Biochem Biophys
;
1991 Aug; 28(4): 227-32
Article
in English
| IMSEAR
| ID: sea-26901
ABSTRACT
The cytotoxic activity of the polyene antibiotics mainly depends on the appearance of the drug species which arises from drug-sterol complexation. The unsaturation and intact macrolide ring of the polyenes are the requirements for the biological activity. All the polyene antibiotics can form the complex with the sterol having 3 beta-OH group, and planar ring and a hydrophobic side chain. Aromatic polyene antibiotics with positively charged head group have been considered as most potential antifungal agents.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Sterols
/
Structure-Activity Relationship
/
Drug Carriers
/
Amphotericin B
/
Filipin
/
Liposomes
/
Animals
/
Membrane Lipids
/
Anti-Bacterial Agents
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1991
Type:
Article
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