Chronic myelogenous leukemia: alterations in red cell membrane band 3 and increased IgG binding.
Indian J Biochem Biophys
;
1990 Dec; 27(6): 456-9
Article
in English
| IMSEAR
| ID: sea-26915
ABSTRACT
Chronic myelogenous leukemia (CML) is a hematologic malignancy arising from an abnormal hemopoietic stem cell. Our earlier studies have identified defects in spectrin tetramer formation and organization of cytoskeletal proteins (Basu et al., Biochim. Biophys. Acta 1988, 121-126); and decreased ankyrin binding to ankyrin-depleted vesicles in CML patients. These may lead to clustering of band 3 and increased binding of autologous IgG. This has now been explored by studying the binding of 125I-protein A to normal and CML erythrocytes. There is increased binding of 125I-protein A in CML erythrocytes compared to normal erythrocytes. Since binding of autologous IgG is responsible for removal of erythrocytes from the circulation, the above findings suggest that CML erythrocytes are likely to be prematurely removed from the circulation, accounting for anemia.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid
/
Staphylococcal Protein A
/
Sulfates
/
Humans
/
Anion Exchange Protein 1, Erythrocyte
/
Immunoglobulin G
/
Blood Proteins
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Ankyrins
/
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1990
Type:
Article
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