Effect of administration of galactosamine hydrochloride on rat liver mitochondria.
Indian J Biochem Biophys
;
1997 Jun; 34(3): 296-301
Article
in English
| IMSEAR
| ID: sea-27103
ABSTRACT
The effect of galactosamine on liver mitochondrial functions was studied in vivo in rats at 12hr, 24hr and 36hr after the administration of the drug. State 3 respiration decreased significantly with both NAD+ linked and FAD linked substrates. Respiratory control ratio, an index of membrane integrity and P/O ratio which is a measure of phosphorylation efficiency decreased significantly. There was a significant decrease in the activities of NADH dehydrogenase, succinate dehydrogenase and cytochrome oxidase. A significant decrease was also seen on membrane potential, cytochrome aa3, cytochrome b, cytochrome c and on phospholipids of mitochondria. The observed mitochondrial dysfunctions were related to increased lipid peroxidation, which could cause loss of membrane integrity and a decreased rate of phosphorylation. It is proposed that increased lipid peroxidation was responsible for the inhibition on both oxidation and phosphorylation in mitochondria in galactosamine treated rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phosphorylation
/
Rats
/
Succinate Dehydrogenase
/
Mitochondria, Liver
/
Electron Transport Complex IV
/
Cell Respiration
/
Cytochromes
/
Electron Transport
/
Galactosamine
/
Lipid Peroxides
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1997
Type:
Article
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