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A theoretical study of acriflavin-DNA binding.
Indian J Biochem Biophys ; 1990 Aug; 27(4): 213-8
Article in English | IMSEAR | ID: sea-27130
ABSTRACT
A theoretical study of binding behaviour of acriflavin, a well-known mutagen, with DNA base pairs such as AT, GC, TA and CG has been performed using CNDO/2 method to compute net atomic charges and dipoles located at various centres in acriflavine as well as base pairs. Acriflavine-DNA base pair interactions have been evaluated using second order perturbation method with multicentered multipole approximation. Only minimum energy configurations have been reported. Results have been discussed with a view to obtain a comparative behaviour of other similar dyes like proflavine and acridine orange.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Thermodynamics / Base Composition / Binding Sites / Acriflavine / DNA / Models, Chemical Language: English Journal: Indian J Biochem Biophys Year: 1990 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Thermodynamics / Base Composition / Binding Sites / Acriflavine / DNA / Models, Chemical Language: English Journal: Indian J Biochem Biophys Year: 1990 Type: Article