Metabolic analysis of galactose toxicity in Escherichia coli with 2-deoxygalactose as the probe.
Indian J Biochem Biophys
;
1991 Oct-Dec; 28(5-6): 541-5
Article
in English
| IMSEAR
| ID: sea-27175
ABSTRACT
Biochemical basis of galactose toxicity has been studied in gal T mutants (CGSC 4974) using 2-deoxygalactose, a non-metabolizable analogue of galactose, as the probe. It is found that biochemical features of toxicity in wild type cells either with 2-deoxygalactose or with 2-deoxyglucose are very similar to the picture obtained with gal T mutants and the observed bacteriostasis is probably due to futile phosphorylation and not due to any specific inhibitory effect of phosphorylated galactose.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phosphorylation
/
Molecular Probes
/
Escherichia coli
/
Fucose
/
Galactose
/
Mutation
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1991
Type:
Article
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