Quantitative structure-activity relationship studies on benzodiazepine receptor binding: investigation of interaction model.
Indian J Biochem Biophys
;
1993 Jun; 30(3): 181-6
Article
in English
| IMSEAR
| ID: sea-27332
ABSTRACT
With a view to providing perfection to the benzodiazepine receptor model proposed earlier [S P Gupta, R N Saha & V Mulchandani (1992) J. Mol. Recog, 5, 75-80] a few more QSAR studies on a series of 9-benzylpurines and tetracyclic 1,4-benzodiazepine derivatives have been made. The models showing the interaction of these compounds with the receptor are proposed. It is found that the receptor model, unlike the one proposed earlier, requires the presence of a polar site along with all the other essential sites.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Protein Conformation
/
Structure-Activity Relationship
/
Benzodiazepines
/
Binding, Competitive
/
Binding Sites
/
Kinetics
/
Molecular Structure
/
Receptors, GABA-A
/
Diazepam
Language:
English
Journal:
Indian J Biochem Biophys
Year:
1993
Type:
Article
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